Nature Communications (Dec 2018)

A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells

  • Jovylyn Gatchalian,
  • Shivani Malik,
  • Josephine Ho,
  • Dong-Sung Lee,
  • Timothy W. R. Kelso,
  • Maxim N. Shokhirev,
  • Jesse R. Dixon,
  • Diana C. Hargreaves

DOI
https://doi.org/10.1038/s41467-018-07528-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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The BAF complex is a multi-subunit chromatin remodeling complex that plays important roles in transcription regulation. Here the authors provide evidence that BRD9 and GLTSCR1/BICRA or its paralog GLTSCR1-like/BICRAL define a non-canonical BAF complex that regulates naive pluripotency in mouse embryonic stem cells.