Serum Neopterin, Retinol and Alpha-tocopherol in Patients with the Carcinoma of the Esophagus
Cincibuch Jan,
Melichar Bohuslav,
Študentová Hana,
Kapustová Miloslava,
Malírová Eva,
Solichová Dagmar,
Krcmová Lenka,
Kašparová Markéta,
Schneiderka Petr,
Juránová Jarmila,
Šrámek Vlastislav,
Cwiertka Karel
Affiliations
Cincibuch Jan
Department of Oncology, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Melichar Bohuslav
Department of Oncology, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Študentová Hana
Department of Oncology, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Kapustová Miloslava
Department of Clinical Biochemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Malírová Eva
Department of Nuclear Medicine, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Solichová Dagmar
Department of Gerontology and Metabolic Care, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Krcmová Lenka
Department of Gerontology and Metabolic Care, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Kašparová Markéta
Department of Gerontology and Metabolic Care, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Schneiderka Petr
Department of Clinical Biochemistry, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Juránová Jarmila
Hematology, Palacký University Medical School and Teaching Hospital, Olomouc, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Šrámek Vlastislav
Department of Oncology, Charles University School of Pharmacy, Hradec Králové, Czech Republic
Cwiertka Karel
Department of Oncology, Palacký University Medical School & Teaching Hospital, I.P. Pavlova 6, 775 20 Olomouc, Czech Republic, phone: +420-588444288, fax: +420-588442522
Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with esophageal carcinoma are scanty. We have studied serum neopterin, retinol and alpha-tocopherol in 45 patients with carcinoma of the esophagus or gastroesophageal junction. Serum neopterin was determined using radioimmunoassay. Retinol and alpha-tocopherol were determined by high-performance liquid chromatography. Serum neopterin in patients with carcinoma of the esophagus was significantly increased while retinol and alpha-tocopherol were significantly decreased compared to controls. No correlation of neopterin with hemoglobin or peripheral blood cell counts was observed. During chemoradiation, neopterin increased significantly, while retinol and alpha-tocopherol did not change. In conclusion, the present study demonstrates increased serum neopterin and decreased retinol and alpha-tocopherol concentrations in patients with esophageal carcinoma. Chemoradiation induced a further increase of serum neopterin concentrations.
