Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

Wei Hou; Wei Hou; Wing-Kin Syn; Wing-Kin Syn

doi:10.3389/fcell.2018.00150

Frontiers in Cell and Developmental Biology (Nov 2018)

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis

Wei Hou,
Wei Hou,
Wing-Kin Syn,
Wing-Kin Syn

Affiliations

Wei Hou: Tianjin Second People’s Hospital and Tianjin Institute of Hepatology, Tianjin, China
Wei Hou: Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States
Wing-Kin Syn: Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States
Wing-Kin Syn: Section of Gastroenterology, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, United States

DOI: https://doi.org/10.3389/fcell.2018.00150
Journal volume & issue: Vol. 6

Abstract

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Activation of hepatic stellate cell (HSC) involves the transition from a quiescent to a proliferative, migratory, and fibrogenic phenotype (i.e., myofibroblast), which is characteristic of liver fibrogenesis. Multiple cellular and molecular signals which contribute to HSC activation have been identified. This review specially focuses on the metabolic changes which impact on HSC activation and fibrogenesis.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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