CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells

Min Xiao; Shoujun Bai; Jing Chen; Yaxi Li; Shu Zhang; Zhao Hu

doi:10.1186/s13098-021-00725-5

Diabetology & Metabolic Syndrome (Oct 2021)

CDKN2B-AS1 participates in high glucose-induced apoptosis and fibrosis via NOTCH2 through functioning as a miR-98-5p decoy in human podocytes and renal tubular cells

Min Xiao,
Shoujun Bai,
Jing Chen,
Yaxi Li,
Shu Zhang,
Zhao Hu

Affiliations

Min Xiao: Department of Nephrology, Qilu Hospital, Cheeloo College of Medicine, Shandong University
Shoujun Bai: Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated To Fudan University
Jing Chen: School of Basic Medical Sciences, Ningxia Medical University
Yaxi Li: Department of Biomedical Engineering, University of Houston
Shu Zhang: Department of Biomedical Engineering, University of Houston
Zhao Hu: Department of Nephrology, Qilu Hospital, Cheeloo College of Medicine, Shandong University

DOI: https://doi.org/10.1186/s13098-021-00725-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Highlights 1. CDKN2B-AS1 was upregulated in DN and high glucose-induced HPCs and HK-2 cells. 2. Inhibition of CDKN2B-AS1 alleviated high glucose-induced apoptosis and fibrosis of HPCs and HK-2 cells. 3. CDKN2B-AS1 regulated NOTCH2 expression via acting as a miR-98-5p sponge.

Published in Diabetology & Metabolic Syndrome

ISSN: 1758-5996 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Nutritional diseases. Deficiency diseases
Website: https://dmsjournal.biomedcentral.com

About the journal

Abstract

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