Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

Gang Zhang; Blanca Lopez Mendez; Garry G. Sedgwick; Jakob Nilsson

doi:10.1038/ncomms12256

Nature Communications (Jul 2016)

Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

Gang Zhang,
Blanca Lopez Mendez,
Garry G. Sedgwick,
Jakob Nilsson

Affiliations

Gang Zhang: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Blanca Lopez Mendez: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Garry G. Sedgwick: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences
Jakob Nilsson: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences

DOI: https://doi.org/10.1038/ncomms12256
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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