Role of Vitamin D and Haemoglobin Levels in Prediabetic Patients- A Retrospective Study

Abstract

Introduction: The 25-hydroxy (OH)D3 (Vitamin D, Cholecalciferol) and Haemoglobin (Hb) level have a significant role in the regulation of immune response. A decrease in Vitamin D and haemoglobin concentrations is a common risk factor for diabetes. The link between Vitamin D and insulin resistance has been studied more thoroughly in patients with diabetes mellitus, although data from people with prediabetes is scarce. Aim: To study the association of Vitamin D and Hb levels in prediabetes patients. Materials and Methods: This retrospective study was conducted in the Sree Balaji Medical College and Hospital, Chennai from July 2020 to December 2020. Total 100 subjects with prediabetes conditions were included and their Vitamin D and Hb levels were measured. The patients who gave written informed consent for prediabetes screening according to ADA-2020 recommendations for prediabetes were included and their Vitamin D and Hb level done as part of the routine check-up were collected. Data were statistically analysed using Analysis of Variance (ANOVA) and Chi-square test. Results: Data of total 100 patients was analysed, including 68 female patients and 32 male patients. Out of 100 patients, 84 were aged between 25-50 years and 16 were aged between 51-65 years. The difference between male and female were statistically significant with p-value <0.01 (for Hb) and p value 0.05 (Vit-D), respectively. A significant difference in mean Hb level when compared among Vitamin D deficient (0.0-19.99 IU/mL) level, insufficient (20-29.99 IU/mL) and sufficient (30-99.99 IU/mL) subjects (p=0.008) was observed. Conclusion: Low levels of Vitamin D is significantly associated with low Hb level. The patients with deficient Vitamin D level showed a significantly low mean Hb level compared to insufficient and sufficient Vitamin D level.

Keywords

• cholecalciferol
• diabetes
• immune response
• insulin resistance