Communications Biology (Dec 2022)

Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC

  • Priyanka Devi-Marulkar,
  • Solène Fastenackels,
  • Pierre Karapentiantz,
  • Jérémy Goc,
  • Claire Germain,
  • Hélène Kaplon,
  • Samantha Knockaert,
  • Daniel Olive,
  • Marylou Panouillot,
  • Pierre Validire,
  • Diane Damotte,
  • Marco Alifano,
  • Juliette Murris,
  • Sandrine Katsahian,
  • Myriam Lawand,
  • Marie-Caroline Dieu-Nosjean

DOI
https://doi.org/10.1038/s42003-022-04356-y
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 16

Abstract

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Regulatory T cells (Tregs) have similar immune profiles in tertiary lymphoid structures of lung cancer and non-TLS areas, with tumor-infiltrating Tregs found to inhibit the proliferation and cytokine secretion of CD4 + conventional T cells.