Nature Communications (Mar 2016)

Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells

  • Florian Rubelt,
  • Christopher R. Bolen,
  • Helen M. McGuire,
  • Jason A. Vander Heiden,
  • Daniel Gadala-Maria,
  • Mikhail Levin,
  • Ghia M. Euskirchen,
  • Murad R. Mamedov,
  • Gary E. Swan,
  • Cornelia L. Dekker,
  • Lindsay G. Cowell,
  • Steven H. Kleinstein,
  • Mark M. Davis

DOI
https://doi.org/10.1038/ncomms11112
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoires.