Nature Communications (Mar 2016)
Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
Abstract
The diversity of antigen receptor specificities is largely generated by random recombination of its segments. Here the authors show, by genetic comparison of monozygotic twin lymphocyte subsets, that individual genetic and epigenetic biases also contribute to the shape of the B and T cell repertoires.