Mitigation of Socio-Economical Inequalities on the Profile of Healthcare Workers Infected with SARS-CoV-2 upon Vaccination: The Experience of a Brazilian Public Healthcare Institution during the Omicron Wave
Maria Celia Chaves Zuma,
Roberta Soares Faccion,
Ana Carolina Carioca da Costa,
Leonardo Henrique Ferreira Gomes,
Daniella Campelo Batalha Cox Moore,
Saint Clair Gomes Junior,
Adriana Cesar Bonomo,
Wilson Savino,
Sotiris Missailidis,
Zilton Farias Meira Vasconcelos
Affiliations
Maria Celia Chaves Zuma
Laboratório de Alta Complexidade (LACIFF), Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 22250-020, Brazil
Roberta Soares Faccion
Laboratório de Alta Complexidade (LACIFF), Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 22250-020, Brazil
Ana Carolina Carioca da Costa
Unidade de Pesquisa Clínica, IFF, FIOCRUZ, Rio de Janeiro 22250-020, Brazil
Leonardo Henrique Ferreira Gomes
Laboratório de Alta Complexidade (LACIFF), Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 22250-020, Brazil
Daniella Campelo Batalha Cox Moore
Departamento de Pediatria, Unidade de Terapia Intensiva, IFF, FIOCRUZ, Rio de Janeiro 22250-020, Brazil
Saint Clair Gomes Junior
Unidade de Pesquisa Clínica, IFF, FIOCRUZ, Rio de Janeiro 22250-020, Brazil
Adriana Cesar Bonomo
Laboratório de Pesquisas Sobre o Timo, Instituto Oswaldo Cruz (IOC), FIOCRUZ, Rio de Janeiro 21045-900, Brazil
Wilson Savino
Laboratório de Pesquisas Sobre o Timo, Instituto Oswaldo Cruz (IOC), FIOCRUZ, Rio de Janeiro 21045-900, Brazil
Sotiris Missailidis
Laboratório de Tecnologia Imunológica, Instituto de Tecnologia em Imunobiológicos, Bio-Manguinhos, FIOCRUZ, Rio de Janeiro 21040-900, Brazil
Zilton Farias Meira Vasconcelos
Laboratório de Alta Complexidade (LACIFF), Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira (IFF), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro 22250-020, Brazil
Background: COVID-19 increased health inequalities worldwide. Even among healthcare workers, social-economical features enhanced the risk of infection (having positive serology) during the first outbreak. The Omicron variant changed the pandemic course and differs from previous variants in many aspects (molecular, clinical, and epidemiological). Herein, we investigated if the profile of our hospital SARS-CoV-2-positive workers during the Omicron outbreak was the same as the first COVID-19 wave. Methods: Socio-demographics, previous infection, and vaccine status of 351 healthcare workers from our institution during the Omicron outbreak were compared between SARS-CoV-2-negative and -positive workers, using chi-square tests. These data were confronted with the profile observed at the beginning of the pandemic. Results: Compared to the original COVID-19 wave, higher odds of SARS-CoV-2 positivity in highly exposed workers in our hospital and a loss of impact of public transportation and other socio-demographic features in SARS-CoV-2 transmission were observed. Conclusions: Our data suggest the current phase of the pandemic is associated with a reduction of social inequalities among healthcare workers in Rio de Janeiro, possibly due to vaccine-associated protection. Therefore, a worldwide effort to advance vaccination coverage, especially for healthcare workers in developing countries, should be reinforced.
