Magnetic resonance imaging technique to quantify biomarkers for chronic liver diseases

Abstract

Background. Recently, multiparametric magnetic resonance imaging (MRI) techniques have been developed to stratify clinically significant changes in chronic liver diseases (CLD). The advantage of multiparametric MRI is the visualization of the entire organ to eliminate the variability of the results during biopsy and the assessment of the quantitative characteristics of individual parameters of the liver parenchyma. A relatively new direction is the use of multiparametric MRI for the diagnosis of CLD with quantitative determination of fat, iron and fibrous changes in the liver parenchyma.Aim. To develop a multiparametric MRI technique for the quantitative assessment of biomarkers in CLD.Object and methods. A multiparametric MR study was performed in 57 patients with CLD using various pulse sequences.Conclusion. The article reflects the developed multiparametric MRI technique for quantifying biomarkers in CLD, based on data of which it is possible to abandon invasive interventions in the process of diagnosis and monitoring the response to treatment.

Keywords

• chronic liver diseases
• magnetic resonance imaging
• biomarker
• proton density of fat fraction
• r2* of water
• fatty hepatosis
• fibrosis
• cirrhosis