Communications Biology (Feb 2023)

Nucleated red blood cells explain most of the association between DNA methylation and gestational age

  • Kristine L. Haftorn,
  • William R. P. Denault,
  • Yunsung Lee,
  • Christian M. Page,
  • Julia Romanowska,
  • Robert Lyle,
  • Øyvind E. Næss,
  • Dana Kristjansson,
  • Per M. Magnus,
  • Siri E. Håberg,
  • Jon Bohlin,
  • Astanand Jugessur

DOI
https://doi.org/10.1038/s42003-023-04584-w
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 11

Abstract

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CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.