Vaccines (Jun 2021)

Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease

  • William Walkowski,
  • Justin Bassett,
  • Manmeet Bhalla,
  • Blaine A. Pfeifer,
  • Elsa N. Bou Ghanem

DOI
https://doi.org/10.3390/vaccines9060589
Journal volume & issue
Vol. 9, no. 6
p. 589

Abstract

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This mini-review will cover recent trends in intranasal (IN) vaccine delivery as it relates to applications for respiratory tract diseases. The logic and rationale for IN vaccine delivery will be compared to methods and applications accompanying this particular administration route. In addition, we will focus extended discussion on the potential role of IN vaccination in the context of respiratory tract diseases, with a special emphasis on pneumococcal disease. Here, elements of this disease, including its prevalence and impact upon the elderly population, will be viewed from the standpoint of improving health outcomes through vaccine design and delivery technology and how IN administration can play a role in such efforts.

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