Nature Communications (May 2021)

Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week

  • Yawei Hu,
  • Xizhao Sui,
  • Fan Song,
  • Yaqian Li,
  • Kaiyi Li,
  • Zhongyao Chen,
  • Fan Yang,
  • Xiuyuan Chen,
  • Yaohua Zhang,
  • Xianning Wang,
  • Qiang Liu,
  • Cong Li,
  • Binbin Zou,
  • Xiaofang Chen,
  • Jun Wang,
  • Peng Liu

DOI
https://doi.org/10.1038/s41467-021-22676-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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The lengthy time in establishing patient-derived organoids(PDOs) hampers the implementation of PDO-based drug sensitivity tests in clinics. Here, the authors show a microwell array-based method to predict patient’s responses to anti-cancer therapies in a week using lung cancer organoids.