BEX1 is an RNA-dependent mediator of cardiomyopathy

Federica Accornero; Tobias G. Schips; Jennifer M. Petrosino; Shan-Qing Gu; Onur Kanisicak; Jop H. van Berlo; Jeffery D. Molkentin

doi:10.1038/s41467-017-02005-1

Nature Communications (Nov 2017)

BEX1 is an RNA-dependent mediator of cardiomyopathy

Federica Accornero,
Tobias G. Schips,
Jennifer M. Petrosino,
Shan-Qing Gu,
Onur Kanisicak,
Jop H. van Berlo,
Jeffery D. Molkentin

Affiliations

Federica Accornero: Cincinnati Children’s Hospital Medical Center
Tobias G. Schips: Cincinnati Children’s Hospital Medical Center
Jennifer M. Petrosino: Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State University
Shan-Qing Gu: Dorothy M. Davis Heart and Lung Research Institute, Department of Physiology and Cell Biology, Ohio State University
Onur Kanisicak: Cincinnati Children’s Hospital Medical Center
Jop H. van Berlo: Cincinnati Children’s Hospital Medical Center
Jeffery D. Molkentin: Cincinnati Children’s Hospital Medical Center

DOI: https://doi.org/10.1038/s41467-017-02005-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Little is known about the changes in mRNA splicing, processing and stability that can alter gene expression during heart failure. Here, the authors show that BEX1 is induced during heart failure and is part of a ribonucleoprotein complex enhancing the expression and stability of proinflammatory genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal