Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

André Franz; Paul A. Pirson; Domenic Pilger; Swagata Halder; Divya Achuthankutty; Hamid Kashkar; Kristijan Ramadan; Thorsten Hoppe

doi:10.1038/ncomms10612

Nature Communications (Feb 2016)

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression

André Franz,
Paul A. Pirson,
Domenic Pilger,
Swagata Halder,
Divya Achuthankutty,
Hamid Kashkar,
Kristijan Ramadan,
Thorsten Hoppe

Affiliations

André Franz: Institute for Genetics and CECAD Research Center, University of Cologne
Paul A. Pirson: Institute for Genetics and CECAD Research Center, University of Cologne
Domenic Pilger: Institute for Genetics and CECAD Research Center, University of Cologne
Swagata Halder: Department of Oncology, University of Oxford, Cancer Research UK/Medical Research Council Oxford, Institute for Radiation Oncology
Divya Achuthankutty: Department of Oncology, University of Oxford, Cancer Research UK/Medical Research Council Oxford, Institute for Radiation Oncology
Hamid Kashkar: Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene at CECAD Research Center, University Hospital of Cologne
Kristijan Ramadan: Department of Oncology, University of Oxford, Cancer Research UK/Medical Research Council Oxford, Institute for Radiation Oncology
Thorsten Hoppe: Institute for Genetics and CECAD Research Center, University of Cologne

DOI: https://doi.org/10.1038/ncomms10612
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Cdc48/p97 is a key component of the ubiquitin-proteasome system, acting as a ubiquitin-directed segregase to regulate multiple cellular functions. Here the authors identify UBXN-3/FAF1 as a crucial regulator of chromatin-associated protein degradation that recruits Cdc48/p97 to DNA replication forks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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