Data on lung and intestinal microbiome after air pollution exposure in ageing rats
Vincent Laiman,
Yu-Chun Lo,
Hsin-Chang Chen,
Tzu-Hsuen Yuan,
Ta-Chih Hsiao,
Jen-Kun Chen,
Ching-Wen Chang,
Ting-Chun Lin,
Ssu-Ju Li,
You-Yin Chen,
Didik Setyo Heriyanto,
Kian Fan Chung,
Kai-Jen Chuang,
Kin-Fai Ho,
Jer-Hwa Chang,
Hsiao-Chi Chuang
Affiliations
Vincent Laiman
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada – Dr. Sardjito Hospital, Yogyakarta, Indonesia
Yu-Chun Lo
Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
Hsin-Chang Chen
Department of Chemistry, College of Science, Tunghai University, Taichung, Taiwan.
Tzu-Hsuen Yuan
Department of Health and Welfare, College of City Management, University of Taipei, Taipei, Taiwan
Ta-Chih Hsiao
Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan
Jen-Kun Chen
Institute of Biomedical Engineering & Nanomedicine, National Health Research Institutes, Miaoli, Taiwan
Ching-Wen Chang
Industrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ting-Chun Lin
Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
Ssu-Ju Li
Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
You-Yin Chen
Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Industrial Ph.D. Program of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan
Didik Setyo Heriyanto
Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada – Dr. Sardjito Hospital, Yogyakarta, Indonesia
Kian Fan Chung
National Heart and Lung Institute, Imperial College London, London, UK
Kai-Jen Chuang
School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Kin-Fai Ho
School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong
Jer-Hwa Chang
School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wuxing Street, Taipei 11031, Taiwan; Division of Pulmonary Medicine, Departments of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Corresponding authors.
Hsiao-Chi Chuang
National Heart and Lung Institute, Imperial College London, London, UK; School of Respiratory Therapy, College of Medicine, Taipei Medical University, 250 Wuxing Street, Taipei 11031, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Corresponding authors.
Air pollution has been linked to respiratory diseases, and urban air pollution can be attributed to a number of emission sources. The emitted particles and gases are the primary components of air pollution that enter the lungs during respiration. Particulate matter with an aerodynamic diameter of ≤ 2.5 µm (PM2.5) can deposit deep into the respiratory tract via inhalation and has been proposed as a causative agent for adverse respiratory health. In addition, the lung contains a diverse microbial community (microbiome) that maintains normal homeostasis and is significantly altered in a variety of pulmonary disorders. Air pollution, specifically PM2.5, has previously been shown to significantly alter the composition of the lower airway microbiome, which has been linked to decreased lung function in chronic obstructive pulmonary disease (COPD) patients. Surprisingly, the intestinal microbiome has also been implicated in the modulation of pulmonary inflammatory diseases. Therefore, dysbiosis of the lung and intestinal microbiomes pose significant negative effects on human health.This dataset describes the microbial community profiles of the lungs and intestines of ageing rats exposed to ambient unconcentrated traffic-related air pollution for three months. The whole-body exposure system was equipped with and without high efficiency particulate air (HEPA) filtration (gaseous vs. PM2.5 pollution). The data can provide valuable information on lung and intestinal microbiome changes, including that which was only found after traffic-related air pollution exposure.
