Structural mechanism of laminin recognition by integrin

Takao Arimori; Naoyuki Miyazaki; Emiko Mihara; Mamoru Takizawa; Yukimasa Taniguchi; Carlos Cabañas; Kiyotoshi Sekiguchi; Junichi Takagi

doi:10.1038/s41467-021-24184-8

Nature Communications (Jun 2021)

Structural mechanism of laminin recognition by integrin

Takao Arimori,
Naoyuki Miyazaki,
Emiko Mihara,
Mamoru Takizawa,
Yukimasa Taniguchi,
Carlos Cabañas,
Kiyotoshi Sekiguchi,
Junichi Takagi

Affiliations

Takao Arimori: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University
Naoyuki Miyazaki: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University
Emiko Mihara: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University
Mamoru Takizawa: Division of Matrixome Research and Application, Institute for Protein Research, Osaka University
Yukimasa Taniguchi: Division of Matrixome Research and Application, Institute for Protein Research, Osaka University
Carlos Cabañas: Cell-cell Communication & Inflammation Unit, Centro de Biología Molecular Severo Ochoa (CSIC-UAM)
Kiyotoshi Sekiguchi: Division of Matrixome Research and Application, Institute for Protein Research, Osaka University
Junichi Takagi: Laboratory for Protein Synthesis and Expression, Institute for Protein Research, Osaka University

DOI: https://doi.org/10.1038/s41467-021-24184-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular detail.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal