Crystal structure and Hirshfeld surface analysis of ketorolac tromethamine

Abstract

Ketorolac tromethamine or 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate, C15H12NO3+·C4H12NO3−, was studied by single-crystal and powder X-ray diffraction methods. One cation and one anion are present in the asymmetric unit. In the crystal, N—H...O and O—H...O hydrogen bonds link the cation and anion. All the hydrogen-bond interactions result in the formation of a di-periodic layer in the (100) crystallographic plane.

Keywords

• ketorolac tromethamine
• molecular structure
• crystal structure
• hirshfeld surface analysis