Nature Communications (Nov 2019)
Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization
- Pei Liu,
- Sixia Huang,
- Shifeng Ling,
- Shuqin Xu,
- Fuhua Wang,
- Wei Zhang,
- Rujiang Zhou,
- Lin He,
- Xuechun Xia,
- Zhengju Yao,
- Ying Fan,
- Niansong Wang,
- Congxia Hu,
- Xiaodong Zhao,
- Haley O. Tucker,
- Jiqiu Wang,
- Xizhi Guo
Affiliations
- Pei Liu
- Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Sixia Huang
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Shifeng Ling
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Shuqin Xu
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Fuhua Wang
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Wei Zhang
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Rujiang Zhou
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Lin He
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Xuechun Xia
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Zhengju Yao
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University
- Ying Fan
- Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Niansong Wang
- Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Congxia Hu
- School of Biomedical Engineering, Shanghai Jiao Tong University
- Xiaodong Zhao
- Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
- Haley O. Tucker
- Institute for Cellular and Molecular Biology, University of Texas at Austin
- Jiqiu Wang
- Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Xizhi Guo
- Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-019-12988-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Beta3-adrenergic receptor (b3-AR) signaling in response to cold activates adipose tissue thermogenesis. Here the authors identify the transcription factor FoxP1 as a direct negative regulator of b3-AR expression and show that loss of FoxP1 leads to enhanced development of thermogenic adipose tissue.
