Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Martina Schweiger; Matthias Romauch; Renate Schreiber; Gernot F. Grabner; Sabrina Hütter; Petra Kotzbeck; Pia Benedikt; Thomas O. Eichmann; Sohsuke Yamada; Oskar Knittelfelder; Clemens Diwoky; Carina Doler; Nicole Mayer; Werner De Cecco; Rolf Breinbauer; Robert Zimmermann; Rudolf Zechner

doi:10.1038/ncomms14859

Nature Communications (Mar 2017)

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Martina Schweiger,
Matthias Romauch,
Renate Schreiber,
Gernot F. Grabner,
Sabrina Hütter,
Petra Kotzbeck,
Pia Benedikt,
Thomas O. Eichmann,
Sohsuke Yamada,
Oskar Knittelfelder,
Clemens Diwoky,
Carina Doler,
Nicole Mayer,
Werner De Cecco,
Rolf Breinbauer,
Robert Zimmermann,
Rudolf Zechner

Affiliations

Martina Schweiger: Institute of Molecular Biosciences, University of Graz
Matthias Romauch: Institute of Molecular Biosciences, University of Graz
Renate Schreiber: Institute of Molecular Biosciences, University of Graz
Gernot F. Grabner: Institute of Molecular Biosciences, University of Graz
Sabrina Hütter: Institute of Molecular Biosciences, University of Graz
Petra Kotzbeck: Institute of Molecular Biosciences, University of Graz
Pia Benedikt: Institute of Molecular Biosciences, University of Graz
Thomas O. Eichmann: Institute of Molecular Biosciences, University of Graz
Sohsuke Yamada: Institute of Molecular Biosciences, University of Graz
Oskar Knittelfelder: Institute of Molecular Biosciences, University of Graz
Clemens Diwoky: Institute of Molecular Biosciences, University of Graz
Carina Doler: Institute of Organic Chemistry, Graz University of Technology
Nicole Mayer: Institute of Organic Chemistry, Graz University of Technology
Werner De Cecco: Institute of Chemistry, University of Graz
Rolf Breinbauer: Institute of Organic Chemistry, Graz University of Technology
Robert Zimmermann: Institute of Molecular Biosciences, University of Graz
Rudolf Zechner: Institute of Molecular Biosciences, University of Graz

DOI: https://doi.org/10.1038/ncomms14859
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

The enzyme Atgl participates in the breakdown of lipids in adipose tissue. Here the authors show that pharmacological inhibition of Atgl reduces weight gain and improves metabolic health in mice fed a high-fat diet, without causing adverse effects in cardiac muscle associated with genetic depletion ofAtgl.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal