Synthesis of Phthalimides: A New Entry via TBAI-Catalyzed Intramolecular Cyclization of 2-(Hydroxymethyl)benzamides

Kare Nagaraju; Nomula Rajesh; Palakodety Radha Krishna

doi:10.1055/s-0037-1609517

SynOpen (Apr 2018)

Synthesis of Phthalimides: A New Entry via TBAI-Catalyzed Intramolecular Cyclization of 2-(Hydroxymethyl)benzamides

Kare Nagaraju,
Nomula Rajesh,
Palakodety Radha Krishna

Affiliations

Kare Nagaraju: D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology
Nomula Rajesh: D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology
Palakodety Radha Krishna: D-211, Discovery Laboratory, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology

DOI: https://doi.org/10.1055/s-0037-1609517
Journal volume & issue: Vol. 02, no. 02
pp. 0145 – 0149

Abstract

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Abstract Herein we report an unprecedented metal-free TBAI/TBHP mediated C–N bond formation via intramolecular cyclization of 2-(hydroxymethyl)benzamides to furnish N-substituted phthalimides in excellent yields.

Published in SynOpen

ISSN: 2509-9396 (Online)
Publisher: Georg Thieme Verlag KG
Country of publisher: Germany
LCC subjects: Science: Chemistry
Website: https://doi.org/10.1055/s-00032269

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Abstract

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