Nature Communications (Aug 2018)
LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation
- Eun-Jin Bae,
- Dong-Kyu Kim,
- Changyoun Kim,
- Michael Mante,
- Anthony Adame,
- Edward Rockenstein,
- Ayse Ulusoy,
- Michael Klinkenberg,
- Ga Ram Jeong,
- Jae Ryul Bae,
- Cheolsoon Lee,
- He-Jin Lee,
- Byung-Dae Lee,
- Donato A. Di Monte,
- Eliezer Masliah,
- Seung-Jae Lee
Affiliations
- Eun-Jin Bae
- Departments of Biomedical Sciences and Medicine, Neuroscience Research Institute, Seoul National University College of Medicine
- Dong-Kyu Kim
- Departments of Biomedical Sciences and Medicine, Neuroscience Research Institute, Seoul National University College of Medicine
- Changyoun Kim
- Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Michael Mante
- Department Neurosciences, School of Medicine, University of California, San Diego
- Anthony Adame
- Department Neurosciences, School of Medicine, University of California, San Diego
- Edward Rockenstein
- Department Neurosciences, School of Medicine, University of California, San Diego
- Ayse Ulusoy
- German Center for Neurodegenerative Diseases (DZNE)
- Michael Klinkenberg
- German Center for Neurodegenerative Diseases (DZNE)
- Ga Ram Jeong
- Department of Neuroscience, Graduate School, Kyung Hee University
- Jae Ryul Bae
- Department of Neuroscience, Graduate School, Kyung Hee University
- Cheolsoon Lee
- Department of Anatomy, School of Medicine, Konkuk University
- He-Jin Lee
- Department of Anatomy, School of Medicine, Konkuk University
- Byung-Dae Lee
- Department of Physiology, School of Medicine, Kyung Hee University
- Donato A. Di Monte
- German Center for Neurodegenerative Diseases (DZNE)
- Eliezer Masliah
- Molecular Neuropathology Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
- Seung-Jae Lee
- Departments of Biomedical Sciences and Medicine, Neuroscience Research Institute, Seoul National University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-05958-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Mutations in LRRK2 kinase are associated with Parkinson’s disease. Here the authors show that LRRK2 modulates propagation of α-synuclein, using rodent and C. elegans models, and show that this is dependent on phosphorylation of one of its substrates, RAB35.
