Nature Communications (Apr 2017)

Structural and functional analysis of the human POT1-TPP1 telomeric complex

  • Cory Rice,
  • Prashanth Krishna Shastrula,
  • Andrew V. Kossenkov,
  • Robert Hills,
  • Duncan M. Baird,
  • Louise C. Showe,
  • Tzanko Doukov,
  • Susan Janicki,
  • Emmanuel Skordalakes

DOI
https://doi.org/10.1038/ncomms14928
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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POT1 and TTP1 are part of the shelterin complex that caps and stabilizes the ends of telomeres. Here the authors present a structural analysis of the human POT1-TTP1 complex, shedding light on how it assembles and how cancer-associated mutations impact its assembly and function.