Nature Communications (Jul 2019)
Active thrombin produced by the intestinal epithelium controls mucosal biofilms
- Jean-Paul Motta,
- Alexandre Denadai-Souza,
- David Sagnat,
- Laura Guiraud,
- Anissa Edir,
- Chrystelle Bonnart,
- Mireille Sebbag,
- Perrine Rousset,
- Ariane Lapeyre,
- Carine Seguy,
- Noa Mathurine-Thomas,
- Heather J. Galipeau,
- Delphine Bonnet,
- Laurent Alric,
- Andre G. Buret,
- John L. Wallace,
- Antoine Dufour,
- Elena F. Verdu,
- Morley D. Hollenberg,
- Eric Oswald,
- Matteo Serino,
- Celine Deraison,
- Nathalie Vergnolle
Affiliations
- Jean-Paul Motta
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Alexandre Denadai-Souza
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- David Sagnat
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Laura Guiraud
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Anissa Edir
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Chrystelle Bonnart
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Mireille Sebbag
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Perrine Rousset
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Ariane Lapeyre
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Carine Seguy
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Noa Mathurine-Thomas
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Heather J. Galipeau
- Farncombe Family Digestive Health Research Institute, McMaster University
- Delphine Bonnet
- Department of Internal Medicine and Digestive Diseases
- Laurent Alric
- Department of Internal Medicine and Digestive Diseases
- Andre G. Buret
- Department of Biological Sciences, University of Calgary
- John L. Wallace
- Departments of Physiology & Pharmacology, and Medicine, University of Calgary Cumming School of Medicine
- Antoine Dufour
- Departments of Physiology & Pharmacology, and Medicine, University of Calgary Cumming School of Medicine
- Elena F. Verdu
- Farncombe Family Digestive Health Research Institute, McMaster University
- Morley D. Hollenberg
- Departments of Physiology & Pharmacology, and Medicine, University of Calgary Cumming School of Medicine
- Eric Oswald
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Matteo Serino
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Celine Deraison
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- Nathalie Vergnolle
- IRSD, Université de Toulouse, INSERM, INRA, ENVT, UPS, U1220, CHU Purpan, CS60039
- DOI
- https://doi.org/10.1038/s41467-019-11140-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
The roles played by thrombin in the human intestinal mucosa are unclear. Here, the authors show that the commensal microbiota modulates epithelial production of active thrombin, which controls biofilm growth and contributes to protection of the mucosa from bacterial invasion.
