(<i>S</i>)-<i>N</i>¹,<i>N</i>³-Dibenzyl-1-cyclohexyl-<i>N</i>¹,<i>N</i>³-bis((<i>R</i>)-1-phenylethyl)propane-1,3-diamine

Abstract

(S)-N1,N3-dibenzyl-1-cyclohexyl-N1,N3-bis((R)-1-phenylethyl)propane-1,3-diamine was prepared in good yield by the reduction of the corresponding amide, which was obtained by the addition of a chiral lithium amide to an α,β-unsaturated ester. The target compound was fully characterized by NMR (1H and 13C), high-resolution mass spectrometry and polarimetry.

Keywords

• 1,3-diamine
• chiral auxiliar
• chiral lithium amide
• organocatalysis
• aza-Michael addition