Canadian Journal of Gastroenterology (Jan 2010)

Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease

  • Lynn Cotterill,
  • Debbie Payne,
  • Scott Levison,
  • John McLaughlin,
  • Emma Wesley,
  • Mark Feeney,
  • Hilary Durbin,
  • Simon Lal,
  • Alistair Makin,
  • Simon Campbell,
  • Stephen A Roberts,
  • Catherine O’Neill,
  • Cathryn Edwards,
  • William G Newman

DOI
https://doi.org/10.1155/2010/480458
Journal volume & issue
Vol. 24, no. 5
pp. 297 – 302

Abstract

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BACKGROUND/OBJECTIVE: Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn’s disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. To assess the effect size of these variants, an independent case-control association study and meta-analysis were performed.