Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

Hyungwoo Lee; Ho-Yeon Lee; Jae-Byoung Chae; Chul-Woo Park; Chaekyu Kim; Ja-Hyoung Ryu; Jiwon Jang; Namshin Kim; Hyewon Chung

doi:10.1038/s42003-022-03676-3

Communications Biology (Jul 2022)

Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

Hyungwoo Lee,
Ho-Yeon Lee,
Jae-Byoung Chae,
Chul-Woo Park,
Chaekyu Kim,
Ja-Hyoung Ryu,
Jiwon Jang,
Namshin Kim,
Hyewon Chung

Affiliations

Hyungwoo Lee: Department of Ophthalmology, Konkuk University School of Medicine
Ho-Yeon Lee: Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology
Jae-Byoung Chae: Department of Ophthalmology, Konkuk University School of Medicine
Chul-Woo Park: Department of Ophthalmology, Konkuk University School of Medicine
Chaekyu Kim: Fusion Biotechnology, Inc.
Ja-Hyoung Ryu: Department of Chemistry, Ulsan National Institute of Science and Technology
Jiwon Jang: Department of Life Sciences, Pohang University of Science and Technology (POSTECH)
Namshin Kim: Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology
Hyewon Chung: Department of Ophthalmology, Konkuk University School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03676-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Single cell transcriptomics pinpoints a cell subpopulation that could be involved in inducing cellular senescence of the retinal pigment epithelium, which in turn may construe retinal degenerative disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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