Nature Communications (Mar 2017)
FMNL formins boost lamellipodial force generation
- Frieda Kage,
- Moritz Winterhoff,
- Vanessa Dimchev,
- Jan Mueller,
- Tobias Thalheim,
- Anika Freise,
- Stefan Brühmann,
- Jana Kollasser,
- Jennifer Block,
- Georgi Dimchev,
- Matthias Geyer,
- Hans-Joachim Schnittler,
- Cord Brakebusch,
- Theresia E. B. Stradal,
- Marie-France Carlier,
- Michael Sixt,
- Josef Käs,
- Jan Faix,
- Klemens Rottner
Affiliations
- Frieda Kage
- Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig
- Moritz Winterhoff
- Institute for Biophysical Chemistry, Hannover Medical School
- Vanessa Dimchev
- Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig
- Jan Mueller
- Institute of Science and Technology Austria
- Tobias Thalheim
- Soft Matter Physics Group, Institut für experimentelle Physik I, Leipzig University
- Anika Freise
- Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig
- Stefan Brühmann
- Institute for Biophysical Chemistry, Hannover Medical School
- Jana Kollasser
- Biomedical Institute, BRIC, University of Copenhagen
- Jennifer Block
- Molecular Cell Biology Group, Helmholtz Centre for Infection Research
- Georgi Dimchev
- Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig
- Matthias Geyer
- Department of Structural Immunology, Institute of Innate Immunity, University of Bonn
- Hans-Joachim Schnittler
- Institute of Anatomy and Vascular Biology, Westfälische Wilhelms-Universität Münster
- Cord Brakebusch
- Biomedical Institute, BRIC, University of Copenhagen
- Theresia E. B. Stradal
- Department of Cell Biology, Helmholtz Centre for Infection Research
- Marie-France Carlier
- Cytoskeleton Dynamics and Motility Group, Laboratoire d'Enzymologie et Biochimie Structurales
- Michael Sixt
- Institute of Science and Technology Austria
- Josef Käs
- Soft Matter Physics Group, Institut für experimentelle Physik I, Leipzig University
- Jan Faix
- Institute for Biophysical Chemistry, Hannover Medical School
- Klemens Rottner
- Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig
- DOI
- https://doi.org/10.1038/ncomms14832
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.
