Obesity-alleviating capabilities of Acalypha indica, Pergulari ademia and Tinospora cardifolia leaves methanolic extracts in WNIN/GR-Ob rats

Abstract

The present study was intended to assess the anti-obesity efficiency of methanolic extracts of leaves of Acalypha indica, Pergularia daemia and Tinospora cordifolia in WNIN/GR-Ob rats. Leaves of three plants were extracted with methanol by using soxhlet apparatus and flash evaporated. WNIN/GR-Ob rats were taken for this study and plant extracts were supplemented to rats in the form of handmade pellets along with standard dietfor 30 days. We evaluated the effects of plant extracts on body and organ weights, blood glucose, and lipid profiles, body composition by TOBEC and DXA and histopathological analysis as well. In the current study, we found that decreased body and organ weights, blood glucose and increased bone mineral density and bone mineral concentration were noticed. We also observed that decreased lipid levels and altered body composition parameters were restored to near normal in treated obese rats when compared to untreated rats. Histopathological study confirmed that these three plant extracts significantly reduced the pathological changes in treated groups caused by obesity. Hence, these results suggest that plant extracts of metanolic extract of A. indica, P. daemia and T. cordifolia (200 mg/kg BW) may be consider in the treatment of obesity. Keywords: Metabolic disorders, Obesity, Acalypha indica, Pergularia daemia, Tinospora cordifolia, Cholesterol, Natural products