Effect of triftazin (trifluoperazine) on the symptoms of autism spectrum disorders in rats with fetal valproatate syndrome

Abstract

The effect of triftazin (trifluoperazine) on social interaction abnormalities as a main feature of autism spectrum disorders, exploratory behavior and learning capacity was studied in rats with fetal valproatate syndrome. It was shown that triftazin at a dose of 0,35 mg/kg does not affect the deficit of social interaction, spatial learning or memory but improves exploratory activity by decreasing anxiety in rats with fetal valproate syndrome.

Keywords

• трифтазин
• вальпроевая кислота
• фетальный вальпроатный синдром
• расстройства аутистического спектра
• социальное взаимодействие
• тревожность
• triftazin
• valproic acid
• fetal valproate syndrome
• autism spectrum disorders
• social interaction
• anxiety