Blood Levels of Indicators of Lower Respiratory Tract Damage in Chronic Bronchitis in Patients with Abdominal Obesity
Elena V. Kashtanova,
Yana V. Polonskaya,
Evgeniia V. Striukova,
Liliia V. Shcherbakova,
Evgenii A. Kurtukov,
Viktoriya S. Shramko,
Ekaterina M. Stakhneva,
Yulia I. Ragino
Affiliations
Elena V. Kashtanova
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Yana V. Polonskaya
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Evgeniia V. Striukova
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Liliia V. Shcherbakova
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Evgenii A. Kurtukov
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Viktoriya S. Shramko
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Ekaterina M. Stakhneva
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Yulia I. Ragino
Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM-Branch of the IC & G SB RAS), st. B.Bogatkova 175/1, 630089 Novosibirsk, Russia
Objective: to study biomolecules associated with pathology in the respiratory system, in particular, with the development of chronic bronchitis in patients with abdominal obesity. Materials and methods: This is a pilot study. The main group consisted of 158 people with chronic bronchitis, divided into two subgroups: one with abdominal obesity, and the other without it. The control group consisted of 68 people without chronic bronchitis. We determined the blood levels of SP-A, SP-D, α1-antitrypsin, CC16, PARC, and RELM-β. Results: In the first subgroup, patients significantly more often complained of coughing, experienced shortness of breath 1.5 times more often with light physical exertion and 2.7 times more often with moderate physical exertion. In these patients, a Tiffeneau–Pinelli index (FEV1/FVC) below 70% was 1.8 times more common, more patients had FEV1 and FVC of less than 80%, and presented a statistically significant decrease in SP-A, α1-antitrypsin, CC16 levels and an increase in PARC levels than in the second subgroup. Conclusion: In patients with chronic bronchitis and abdominal obesity, there is a decrease in the levels of SP-A, α1-antitrypsin, CC16 and an increase in the level of PARC compared with patients without abdominal obesity, which is probably due to the presence of an additional source of chronic inflammation associated with adipose tissue.
