Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J. Young; Joshua S. Friedman; Thomas J. Oxley; Christina Palmese; Fedor Panov; Saadi Ghatan; Johanna T. Fifi; Lara V. Marcuse

Epilepsy and Behavior Case Reports (Jan 2018)

Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection

James J. Young,
Joshua S. Friedman,
Thomas J. Oxley,
Christina Palmese,
Fedor Panov,
Saadi Ghatan,
Johanna T. Fifi,
Lara V. Marcuse

Affiliations

James J. Young: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA; Corresponding author at: Departments of Neurology and Neurosurgery, Icahn School of Medicine at Mount Sinai, 1468 Madison Ave, Annenberg Building, Rm. 210, New York, NY 10029, USA.
Joshua S. Friedman: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Thomas J. Oxley: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Christina Palmese: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Fedor Panov: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Saadi Ghatan: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Johanna T. Fifi: Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA
Lara V. Marcuse: Department of Neurology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA

Journal volume & issue: Vol. 10
pp. 25 – 28

Abstract

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The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity. Keywords: Intracarotid amobarbital procedure, Wada, Stereo-EEG, Synchrony, Phase amplitude coupling, Epilepsy surgery

Published in Epilepsy and Behavior Case Reports

ISSN: 2213-3232 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.journals.elsevier.com/epilepsy-and-behavior-case-reports/

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