Nature Communications (Sep 2016)

MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

  • Stefano Alivernini,
  • Mariola Kurowska-Stolarska,
  • Barbara Tolusso,
  • Roberta Benvenuto,
  • Aziza Elmesmari,
  • Silvia Canestri,
  • Luca Petricca,
  • Antonella Mangoni,
  • Anna Laura Fedele,
  • Clara Di Mario,
  • Maria Rita Gigante,
  • Elisa Gremese,
  • Iain B. McInnes,
  • Gianfranco Ferraccioli

DOI
https://doi.org/10.1038/ncomms12970
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid arthritis.