The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway

Kuang Guiying; Shu Zhigang; Zhu Chunli; Li Hongbing; Zhang Cheng

doi:10.1515/tnsci-2022-0302

Translational Neuroscience (Aug 2023)

The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway

Kuang Guiying,
Shu Zhigang,
Zhu Chunli,
Li Hongbing,
Zhang Cheng

Affiliations

Kuang Guiying: Neurological Department, Wuhan Red Cross Hospital, Wuhan, Hubei Province, 436015, China
Shu Zhigang: Neurological Department, Ezhou Central Hospital, Ezhou, Hubei Province, 436000, China
Zhu Chunli: Neurological Department, Wuhan Red Cross Hospital, Wuhan, Hubei Province, 436015, China
Li Hongbing: Emergency Department, The First People’s Hospital of Guiyang, Guiyang, Guizhou Province, 550002, China
Zhang Cheng: Emergency Department, The First People’s Hospital of Guiyang, Guiyang, Guizhou Province, 550002, China

DOI: https://doi.org/10.1515/tnsci-2022-0302
Journal volume & issue: Vol. 14, no. 1
pp. 4 – 12

Abstract

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The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-like domains (Ang receptor) 2 (Tie-2) signaling pathways, which may underlie the cognitive improvement observed in CCH rats.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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Abstract

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