Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation

Sara Zumerle; Sara Zumerle; Barbara Molon; Barbara Molon; Antonella Viola; Antonella Viola

doi:10.3389/fimmu.2017.01467

Frontiers in Immunology (Nov 2017)

Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation

Sara Zumerle,
Sara Zumerle,
Barbara Molon,
Barbara Molon,
Antonella Viola,
Antonella Viola

Affiliations

Sara Zumerle: Department of Biomedical Sciences, University of Padova, Padova, Italy
Sara Zumerle: Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
Barbara Molon: Department of Biomedical Sciences, University of Padova, Padova, Italy
Barbara Molon: Venetian Institute of Molecular Medicine (VIMM), Padova, Italy
Antonella Viola: Department of Biomedical Sciences, University of Padova, Padova, Italy
Antonella Viola: Pediatric Research Institute “Citta della Speranza”, Padova, Italy

DOI: https://doi.org/10.3389/fimmu.2017.01467
Journal volume & issue: Vol. 8

Abstract

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Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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