Nature Communications (Jun 2018)

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

  • Alexander Rosenberg,
  • Iuliana V. Ene,
  • Maayan Bibi,
  • Shiri Zakin,
  • Ella Shtifman Segal,
  • Naomi Ziv,
  • Alon M. Dahan,
  • Arnaldo Lopes Colombo,
  • Richard J. Bennett,
  • Judith Berman

DOI
https://doi.org/10.1038/s41467-018-04926-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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The authors show that antifungal tolerance, defined as the fraction of growth of a fungal pathogen above the minimal inhibitory concentration, is due to the slow growth of subpopulations of cells that overcome drug stress, and that high tolerance is often associated with persistent infections.