Nature Communications (Feb 2021)
Lasting antibody and T cell responses to SARS-CoV-2 in COVID-19 patients three months after infection
- Xiao-Lin Jiang,
- Guo-Lin Wang,
- Xiang-Na Zhao,
- Fei-Hu Yan,
- Lin Yao,
- Zeng-Qiang Kou,
- Sheng-Xiang Ji,
- Xiao-Li Zhang,
- Cun-Bao Li,
- Li-Jun Duan,
- Yan Li,
- Yu-Wen Zhang,
- Qing Duan,
- Tie-Cheng Wang,
- En-Tao Li,
- Xiao Wei,
- Qing-Yang Wang,
- Xue-Feng Wang,
- Wei-Yang Sun,
- Yu-Wei Gao,
- Dian-Min Kang,
- Ji-Yan Zhang,
- Mai-Juan Ma
Affiliations
- Xiao-Lin Jiang
- Shandong Provincial Center for Disease Control and Prevention
- Guo-Lin Wang
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Xiang-Na Zhao
- Institute of Disease Control and Prevention, Chinese People’s Liberation Army
- Fei-Hu Yan
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- Lin Yao
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Zeng-Qiang Kou
- Shandong Provincial Center for Disease Control and Prevention
- Sheng-Xiang Ji
- Linyi Center for Disease Control and Prevention
- Xiao-Li Zhang
- Linyi Center for Disease Control and Prevention
- Cun-Bao Li
- Linyi Center for Disease Control and Prevention
- Li-Jun Duan
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- Yan Li
- Shandong Provincial Center for Disease Control and Prevention
- Yu-Wen Zhang
- Shandong Provincial Center for Disease Control and Prevention
- Qing Duan
- Shandong Provincial Center for Disease Control and Prevention
- Tie-Cheng Wang
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- En-Tao Li
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- Xiao Wei
- Institute of Disease Control and Prevention, Chinese People’s Liberation Army
- Qing-Yang Wang
- Beijing Institute of Brain Science
- Xue-Feng Wang
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- Wei-Yang Sun
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- Yu-Wei Gao
- Institute of Military Veterinary Medicine, Academy of Military Medical Sciences
- Dian-Min Kang
- Shandong Provincial Center for Disease Control and Prevention
- Ji-Yan Zhang
- Beijing Institute of Brain Science
- Mai-Juan Ma
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
- DOI
- https://doi.org/10.1038/s41467-021-21155-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Understanding if lasting immune responses can be induced by SARS-CoV-2 infection is important for controlling the COVID-19 pandemic. Here, the authors show, in a cohort of 25 patients, that IgG and T cell responses, as well as neutralising antibody, are still detectable against various SARS-CoV-2 proteins 3 months post-symptom onset, while IgM levels largely wane at this time.
