Clinical, biochemical and hormone profile in hirsute vs nonhirsute patients with polycystic ovary syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS), a common endocrinopathy present with variety of phenotypes with broad spectrum of clinical symptoms. Hyperandrogenism characterized with the presence of hirsutism remains an important feature of PCOS. Aim: The present study was conducted to assess difference in the clinical, biochemical and hormone profile in hirsute and non-hirsute females with PCOS. Methods: Detailed physical and clinical history was taken in all subjects. Hormonal and biochemical assays were performed by ECLIA. Results: 105 normoglycemic cases were enrolled for this study. The mean age of patients was 22.19 ±4.4 years and the mean age of menarche was 13.3±1.4 years. Acne was present in more than 50% of our cases. 81% cases were hirsute and only 19% were non-hirsute. Mean fasting blood glucose and triglycerides were found to be statistically significant between the two groups. A positive trend of hirsutism was found to be associated with irregular cycles and family history of type-2 diabetes mellitus (T2DM). Conclusion: The mean blood glucose and triglycerides was elevated in hirsute PCOS, while as BMI, weight and waist circumference was slightly elevated in non-hirsute PCOS females.

Keywords

• polycystic ovary syndrome
• hirsutism
• irregular cycles
• hyperandrogenism
• testosterone