Case Report of Cerebral Sinus Thrombosis Related to Immune Thrombotic Thrombocytopenia Following Administration of ChAdOx1 nCoV-19 for Vaccination against COVID-19
Wojciech Szypowski,
Aleksander Dębiec,
Jarosław Świstak,
Maciej Nowocień,
Piotr Rzepecki,
Marcin Możański,
Jacek Staszewski,
Adam Stępień
Affiliations
Wojciech Szypowski
Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland
Aleksander Dębiec
Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland
Jarosław Świstak
Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland
Maciej Nowocień
Medical Diagnostic Imaging, Military Institute of Medicine, 04-141 Warsaw, Poland
Piotr Rzepecki
Clinic of Haematology, Military Institute of Medicine, 04-141 Warsaw, Poland
Marcin Możański
Clinic of Anaesthesiology and Intensive Care, Military Institute of Medicine, 04-141 Warsaw, Poland
Jacek Staszewski
Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland
Adam Stępień
Clinic of Neurology, Military Institute of Medicine, 04-141 Warsaw, Poland
Vaccine-induced immune thrombotic thrombocytopenia (VITT) with cerebral venous sinus thrombosis (CVST) has been recently reported after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We present a case of a patient with fulminant CVST and thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine. Although the patient received immediate anticoagulant and intravenous immune globulin treatment, he died within 24 h after hospital admission. VITT and CVST are rare conditions; however, the course may be fatal. Therefore, clinicians should be familiarized with the clinical and laboratory features of VITT.
