Nature Communications (Jun 2017)

Cooperative tumour cell membrane targeted phototherapy

  • Heegon Kim,
  • Junsung Lee,
  • Chanhee Oh,
  • Ji-Ho Park

DOI
https://doi.org/10.1038/ncomms15880
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Tumour distribution of targeted therapies is intrinsically heterogeneous. Here, the authors develop a strategy to decorate entire tumour membranes with synthetic receptors for amplified targeting of therapeutics and show that such cooperative membrane-targeted phototherapy results in tumour regression in mice.