The Effect of Statins on the Developing Endotal Dysfunction in Arterioveneic Fistules Opening for Hemodialysis

Abstract

Aim: In this study; we investigated the effects of atorvastatin treatment on endothelial dysfunction (ED) as well as antihyperlipidemic effects of atorvastatin treatment in patients with hemodialysis due to end-stage renal disease for at least 6 months. Materials and Method: In this study, 15 control and 15 atorvastatin patients were examined. Evaluation of ED was performed by evaluating the flow-mediated dilatation of the brachial artery in the fistula which was performed as described previously. Results: Comparing the first and last value difference of LDL with independent T-test for statin given and not given groups; LDL values were statistically significant in statin group (p = 0.000, p <0.01). In addition, the comparison of the first and last value difference of FMD with the independent T-test according to statin given and not given groups: According to the statin group, the FMD values were statistically significant (p = 0.001, p <0.01). Conclusion: In our study, we applied FMD test results to demonstrate endothelial dysfunction; i) statin group is statistically significant in favor of statin group compared to control group, ii) fistula development and patency rate is statistically more meaningful in statin group due to decrease in atherosclerosis development. In view of these findings, we believe that statin use is necessary to ensure short-term fistula patency in statin AVF patients and to protect the dialysis access path without the need for additional processing.

Keywords

• hemodiyaliz
• statinler
• endotelyal disfonksiyon
• hemodiyaliz
• statinler
• endothelial dysfunction