The Role of Strain by Cardiac Magnetic Resonance Imaging in Predicting the Prognosis of Patients with Chronic Thromboembolic Pulmonary Hypertension

Xuefei Zhang MS; Xiaojuan Guo MD; Bowen Zhang MS; Qi Yang MD; Juanni Gong MD; Suqiao Yang MD; Jifeng Li MD; Tuguang Kuang MD; Ran Miao PhD; Yuanhua Yang MD

doi:10.1177/10760296231176253

Clinical and Applied Thrombosis/Hemostasis (Sep 2023)

The Role of Strain by Cardiac Magnetic Resonance Imaging in Predicting the Prognosis of Patients with Chronic Thromboembolic Pulmonary Hypertension

Xuefei Zhang MS,
Xiaojuan Guo MD,
Bowen Zhang MS,
Qi Yang MD,
Juanni Gong MD,
Suqiao Yang MD,
Jifeng Li MD,
Tuguang Kuang MD,
Ran Miao PhD,
Yuanhua Yang MD

Affiliations

Xuefei Zhang MS: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Xiaojuan Guo MD: Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China
Bowen Zhang MS: Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China
Qi Yang MD: Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China
Juanni Gong MD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Suqiao Yang MD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Jifeng Li MD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Tuguang Kuang MD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Ran Miao PhD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China
Yuanhua Yang MD: Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing, China

DOI: https://doi.org/10.1177/10760296231176253
Journal volume & issue: Vol. 29

Abstract

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Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by thrombotic obstruction of the pulmonary arteries, and right ventricular (RV) dysfunction is a major cause of death. Cardiac magnetic resonance (CMR) is the gold standard for assessing heart wall deformation; therefore, we aimed to determine the prognostic value of CMR strain in patients with CTEPH. Strain derived by CMR was measured at the time of diagnosis in 45 patients with CTEPH, and the relationship between RV strain and prognosis was determined through follow-up. The value of RV strain in the prognostic model was compared with that of pulmonary arterial hypertension (PAH) risk stratification. The RV global peak longitudinal strain (GLS) and global peak circumferential strain (GCS) in CTEPH patients were lower than the normal references of RV strain in the control group. GLS and longitudinal strain in the basal segment were independent risk factors for adverse events ( P < .050). Adding CMR parameters to PAH risk stratification improved its predictive power in patients with CTEPH. GLS and GCS scores were impaired in patients with chronic RV overload. RV strain derived by CMR imaging is a promising noninvasive tool for the follow-up of patients with CTEPH.

Published in Clinical and Applied Thrombosis/Hemostasis

ISSN: 1076-0296 (Print); 1938-2723 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://journals.sagepub.com/home/cat

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