Serum Pentosidine is Associated with Cardiac Dysfunction and Atherosclerosis in T2DM

Abstract

Yuyan Cao,1,* Xinhua Ye,1,* Xiaoqing Yuan,1 Juan Liu,1 Qing Zhang2 1Department of Endocrinology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 2Changzhou Medical Center, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan Liu; Qing Zhang, Email [email protected]; [email protected]: The purpose of this paper is to investigate the relationship between serum pentosidine levels and cardiac function and vascular disease in diabetic patients, and to provide a new reference indicator for the early detection of diabetic cardiovascular complications.Materials and Methods: This was a cross-sectional study. One hundred and twenty-two patients with type 2 diabetes were grouped by LVEF quartiles to compare the differences between their clinical data and serum pentosidine levels. Also, the correlation between serum pentosidine and clinical indicators was assessed. The effect of serum pentosidine on cardiac function and vascular stiffness was analyzed by multiple stepwise regression.Results: Serum pentosidine levels were higher in patients with LVEF ≤ 57%. Serum pentosidine levels were positively correlated with waist-to-hip ratio, hemoglobin, AIP, baPWV, LVESD, and ARD, and negatively correlated with LVEF. Low serum pentosidine was associated with increased LVESD; high pentosidine was significantly associated with increased ARD, high AIP and high baPWV.Conclusion: The results suggest that serum pentosidine, a member of AGEs, may reflect cardiac remodeling and dysfunction as well as atherosclerosis.Keywords: pentosidine, T2DM, cardiac dysfunction, atherosclerosis

Keywords

• pentosidine
• t2dm
• cardiac dysfunction
• atherosclerosis