Autoprobiotic therapy

Abstract

The results are presented of the experimental study of survival rates of autologous bifidobacteria and lactobacilli strains (autostrains) in the intestines of conventional white mice and guinea pigs, as well as an assessment of the effectiveness of the use of isolated bifidobacteria and lactobacilli autostrains in the correction of microecological disorders in the intestines of animals with antibiotic-associated dysbacteriosis. Bifidobacteria and lactobacilli autostrains isolated from intestinal contents of conventional white mice and guinea pigs, as well as rifampicin-resistant derivatives of isolated bacterial autostrains were used in the experiments. It is found that rifampicin-resistant derivatives of bifidobacteria and lactobacilli autostrains retain species and genetically fixed sign of antibiotic resistance. Administered orally to experimental animals, autostrains of bifidobacteria and lactobacilli do not survive in the intestines of animals and are eliminated to 4 days after cessation of administration. Bifidobacteria and lactobacilli autostrains exert virtually no influence on the recovery of the intestinal microbiota in experimental animals with antibiotic-associated dysbacteriosis unlike lactobacilli metabolites and prebiotic Stimbifid, efficiently restoring intestinal microbiota in a short time

Keywords

• probiotic
• prebiotic
• metabiotic
• microbiota
• dysbacteriosis
• autostrains
• white mice
• guinea pigs
• autoprobiotic therapy