Case Study: Rosai-Dorfman Disease and Its Multifaceted Aspects

Abstract

Daniela Oliveira Werneck Rodrigues,1,2 Roberta Wolp Diniz,2 Leonardo Cunha Dentz,1 Monica de Albuquerque Costa,3 Roberto Heleno Lopes,2 Lucas Fernandes Suassuna,4 Jane Rocha Duarte Cintra,2 Christian Domenge2 1Department of Medicine, Centro Universitário Presidente Antônio Carlos, Juiz de Fora, MG, Brazil; 2Department of Oncohematology, Hospital 9 de Julho/ Instituto Oncológico de Juiz de Fora, Juiz de Fora, MG, Brazil; 3Department of Dematology, Secretaria de Saúde da Prefeitura Municipal de Juiz de Fora, Juiz de Fora, MG, Brazil; 4Department of Medicine, Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, BrazilCorrespondence: Daniela Oliveira Werneck Rodrigues, Instituto Oncológico de Juiz de Fora, R. Santos Dumont, 56 - Granbery, Juiz de Fora, MG, 36010-510, Brazil, Tel [phone], Email [email protected]: Rosai-Dorfman Disease (RDD) is a rare non-Langerhans histiocytosis, usually self-limited and presenting with massive, painless, bilateral cervical lymphadenopathy, with or without constitutional symptoms. Extranodal disease is frequently present, and may happen in the absence of lymph node involvement, symptomatology and differential diagnosis will depend on the site affected and fatal cases may occur. The authors present two cases of Rosai-Dorfman disease (RDD), diagnosed through immunohistochemistry, with different progressions, one with complete remission and one culminating in death, highlighting the variety of presentations and the diagnostic difficulty. RDD is a rare condition with clinical presentations similar to several diseases, and should be considered in the differential diagnosis of lymphadenopathy with extranodal lesions.Keywords: Rosai Dorfman disease, immunohistochemistry, diagnosis, differential diagnosis (MeSH-NCBI)

Keywords

• rosai dorfman disease
• immunohistochemistry
• diagnosis
• differential diagnosis (mesh-ncbi).