Nature Communications (Jan 2017)

Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

  • Junnan Tang,
  • Deliang Shen,
  • Thomas George Caranasos,
  • Zegen Wang,
  • Adam C. Vandergriff,
  • Tyler A. Allen,
  • Michael Taylor Hensley,
  • Phuong-Uyen Dinh,
  • Jhon Cores,
  • Tao-Sheng Li,
  • Jinying Zhang,
  • Quancheng Kan,
  • Ke Cheng

DOI
https://doi.org/10.1038/ncomms13724
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Stem cells exert their beneficial effects through secretion of regenerative factors. Here, the authors take the membranes and secreted factors from cardiac stem cells and generate a synthetic cell-mimicking microparticle, which, on injection in a mouse model of myocardial infarction, improves cardiac function.