New Neutrophil Parameters in Diseases with Various Inflammatory Processes
Elżbieta Rutkowska,
Iwona Kwiecień,
Agata Raniszewska,
Rafał Sokołowski,
Joanna Bednarek,
Karina Jahnz-Różyk,
Andrzej Chciałowski,
Piotr Rzepecki
Affiliations
Elżbieta Rutkowska
Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland
Iwona Kwiecień
Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland
Agata Raniszewska
Laboratory of Hematology and Flow Cytometry, Department of Internal Medicine and Hematology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland
Rafał Sokołowski
Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, 04-141 Warsaw, Poland
Joanna Bednarek
Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, 04-141 Warsaw, Poland
Karina Jahnz-Różyk
Department of Internal Medicine, Pneumonology, Allergology, Clinical Immunology and Rare Diseases, 04-141 Warsaw, Poland
Andrzej Chciałowski
Department of Internal Medicine, Infectious Diseases and Allergology, 04-141 Warsaw, Poland
Piotr Rzepecki
Department of Internal Medicine and Hematology, Military Institute of Medicine-National Research Institute, 04-141 Warsaw, Poland
The neutrophils evaluation seems interesting in the initial qualifications of patients with various inflammatory processes. In this study, we presented analysis of neutrophils and new parameters of the complexity (NEUT-GI, NE-WX), maturation (IG), size (NE-FSC, NE-WZ), and neutrophil activities (NEUT-RI, NE-WY) in coronavirus disease 2019 (COVID-19), lung cancer (LC), sarcoidosis (SA), and healthy controls (HCs). Peripheral blood (PB) was collected. The new parameters were examined by the Sysmex XN-1500. The mean absolute value for the IG parameter was the highest in the LC group. The differences in NEUT-RI value between COVID-19 and the HC group were observed. No significant differences were noticed between groups in the NEUT-GI granularity parameter. Neutrophil size assessed by NE-FSC parameter was reduced in all groups compared to HCs. The values of complexity (NE-WX), fluorescence (NE-WY), and size (NE-WZ) were the lowest in the HCs, whereas the highest median proportions of NE-WX, NE-WY, and NE-WZ were in LC patients. Patients from the SA group differed significantly from the HC group only for the NE-WZ parameter. We showed the usefulness of neutrophil parameters and their reactivity, morphology, and exhaustion. A more detailed analysis of blood counts may reveal trends that indicate a disease-specific immune response.
