Structural basis for the ARF GAP activity and specificity of the C9orf72 complex

Ming-Yuan Su; Simon A. Fromm; Jonathan Remis; Daniel B. Toso; James H. Hurley

doi:10.1038/s41467-021-24081-0

Nature Communications (Jun 2021)

Structural basis for the ARF GAP activity and specificity of the C9orf72 complex

Ming-Yuan Su,
Simon A. Fromm,
Jonathan Remis,
Daniel B. Toso,
James H. Hurley

Affiliations

Ming-Yuan Su: School of Medicine, Southern University of Science and Technology
Simon A. Fromm: Department of Molecular and Cell Biology, University of California
Jonathan Remis: California Institute for Quantitative Biosciences, University of California
Daniel B. Toso: California Institute for Quantitative Biosciences, University of California
James H. Hurley: Department of Molecular and Cell Biology, University of California

DOI: https://doi.org/10.1038/s41467-021-24081-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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C9orf72:SMCR8:WDR41 complex has been reported to have GAP activity for both ARF family proteins and the RAB proteins RAB8A and RAB11A. Here the authors provide structural and biochemical evidence for a specific function of the C9orf72 complex as an ARF GAP, and a structural framework for the GAP activity of the longin-containing GAP family.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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