Comparing the Efficacy of a Microperforated Titanium Membrane for Guided Bone Regeneration with an Existing Mesh Retainer in Dog Mandibles
Hiroshi Hasegawa,
Tetsuharu Kaneko,
Manabu Endo,
Chihiro Kanno,
Morio Yamazaki,
Sadanoshin Yaginuma,
Hiroki Igarashi,
Hideaki Honma,
Seiichiro Masui,
Mizuki Suto,
Yukihiko Sakisaka,
Hiroshi Ishihata
Affiliations
Hiroshi Hasegawa
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Tetsuharu Kaneko
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Manabu Endo
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Chihiro Kanno
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Morio Yamazaki
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Sadanoshin Yaginuma
Department of Oral Surgery and Dentistry, Fukushima Medical University, 1, Hikariga-oka, Fukushima 960-1295, Japan
Hiroki Igarashi
Department of Dentistry and Oral Surgery, Koseikai Hospital, 16-2, Nariide, Kitasawamata, Fukushima 960-8251, Japan
Hideaki Honma
Department of Dentistry and Oral Surgery, Omachi Hospital, 3-97, Omachi, Haranomachi-ku, Minami-Soma, Fukushima 975-0001, Japan
Seiichiro Masui
Clinical Research Center, Fukushima Medical University Hospital, 1, Hikariga-oka, Fukushima 960-1295, Japan
Mizuki Suto
Division of Periodontology and Endodontology, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Yukihiko Sakisaka
Division of Periodontology and Endodontology, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Hiroshi Ishihata
Division of Periodontology and Endodontology, Department of Ecological Dentistry, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan
Acute-type lateral ridge defects (25 mm × 6 mm × 5 mm) were bilaterally created in the mandibles of four dogs (two defects per animal). The defects were reconstructed with particulate autologous bone and covered with a microperforated titanium membrane (Ti-honeycomb membrane, TiHM) or an existing conventional titanium mesh as control. The samples were dissected after 16 weeks postoperatively and processed for radiographic, histologic, and histomorphometric analyses. Regenerated tissue and bone volume were significantly larger in the TiHM group than in the control group (p = 0.05; p = 0.049). In contrast, bone mineral density was similar between the two groups. Histomorphometric analysis revealed that the regenerated bone area and calcific osseous area were larger in the TiHM group than in the control group; however, the differences were not significant. The efficacy of TiHM was generally satisfactory with the potential to become a standard tool for the GBR procedure; however, early membrane exposure will be a major problem to overcome.
