Nature Communications (Aug 2019)
Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages
- Adeline C. Y. Chua,
- Jessica Jie Ying Ong,
- Benoit Malleret,
- Rossarin Suwanarusk,
- Varakorn Kosaisavee,
- Anne-Marie Zeeman,
- Caitlin A. Cooper,
- Kevin S. W. Tan,
- Rou Zhang,
- Bee Huat Tan,
- Siti Nurdiana Abas,
- Andy Yip,
- Anne Elliot,
- Chester J. Joyner,
- Jee Sun Cho,
- Kate Breyer,
- Szczepan Baran,
- Amber Lange,
- Steven P. Maher,
- François Nosten,
- Christophe Bodenreider,
- Bryan K. S. Yeung,
- Dominique Mazier,
- Mary R. Galinski,
- Nathalie Dereuddre-Bosquet,
- Roger Le Grand,
- Clemens H. M. Kocken,
- Laurent Rénia,
- Dennis E. Kyle,
- Thierry T. Diagana,
- Georges Snounou,
- Bruce Russell,
- Pablo Bifani
Affiliations
- Adeline C. Y. Chua
- Singapore Immunology Network, A*STAR
- Jessica Jie Ying Ong
- Department of Microbiology and Immunology, University of Otago
- Benoit Malleret
- Singapore Immunology Network, A*STAR
- Rossarin Suwanarusk
- Singapore Immunology Network, A*STAR
- Varakorn Kosaisavee
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Anne-Marie Zeeman
- Department of Parasitology, Biomedical Primate Research Centre
- Caitlin A. Cooper
- Center for Tropical and Emerging Global Diseases, University of Georgia
- Kevin S. W. Tan
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Rou Zhang
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Bee Huat Tan
- Novartis Institute for Tropical Diseases
- Siti Nurdiana Abas
- Novartis Institute for Tropical Diseases
- Andy Yip
- Novartis Institute for Tropical Diseases
- Anne Elliot
- Center for Tropical and Emerging Global Diseases, University of Georgia
- Chester J. Joyner
- Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University
- Jee Sun Cho
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Kate Breyer
- Laboratory Animal Services, Scientific Operations, Novartis Institutes for Biomedical Research
- Szczepan Baran
- Laboratory Animal Services, Scientific Operations, Novartis Institutes for Biomedical Research
- Amber Lange
- Laboratory Animal Services, Scientific Operations, Novartis Institutes for Biomedical Research
- Steven P. Maher
- Center for Tropical and Emerging Global Diseases, University of Georgia
- François Nosten
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University
- Christophe Bodenreider
- Novartis Institute for Tropical Diseases
- Bryan K. S. Yeung
- Novartis Institute for Tropical Diseases
- Dominique Mazier
- Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris)
- Mary R. Galinski
- Emory Vaccine Center, Emory University
- Nathalie Dereuddre-Bosquet
- CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department
- Roger Le Grand
- CEA-Université Paris Sud 11-INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department
- Clemens H. M. Kocken
- Department of Parasitology, Biomedical Primate Research Centre
- Laurent Rénia
- Singapore Immunology Network, A*STAR
- Dennis E. Kyle
- Center for Tropical and Emerging Global Diseases, University of Georgia
- Thierry T. Diagana
- Novartis Institute for Tropical Diseases
- Georges Snounou
- Sorbonne Universités, UPMC Univ Paris 06, CR7, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris)
- Bruce Russell
- Department of Microbiology and Immunology, University of Otago
- Pablo Bifani
- Singapore Immunology Network, A*STAR
- DOI
- https://doi.org/10.1038/s41467-019-11332-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Present understanding of Plasmodium vivax biology is hampered by its inability to grow in vitro. Here, the authors developed an in vitro culture of its simian counterpart, P. cynomolgi, which shares morphological and phenotypic similarities with P. vivax, initiating a new phase in vivax research.
